A Finite Domain Constraint Approach for Placement and Routing of Coarse-Grained Reconfigurable Architectures

Scheduling, placement, and routing are important steps in Very Large Scale Integration (VLSI) design. Researchers have developed numerous techniques to solve placement and routing problems. As the complexity of Application Specific Integrated Circuits (ASICs) increased over the past decades, so did the demand for improved place and route techniques. The primary objective of these place and route approaches has typically been wirelength minimization due to its impact on signal delay and design performance. With the advent of Field Programmable Gate Arrays (FPGAs), the same place and route techniques were applied to FPGA-based design. However, traditional place and route techniques may not work for Coarse-Grained Reconfigurable Architectures (CGRAs), which are reconfigurable devices offering wider path widths than FPGAs and more flexibility than ASICs, due to the differences in architecture and routing network. Further, the routing network of several types of CGRAs, including the Field Programmable Object Array (FPOA), has deterministic timing as compared to the routing fabric of most ASICs and FPGAs reported in the literature. This necessitates a fresh look at alternative approaches to place and route designs. This dissertation presents a finite domain constraint-based, delay-aware placement and routing methodology targeting an FPOA. The proposed methodology takes advantage of the deterministic routing network of CGRAs to perform a delay aware placement

Bisphenol-A in Wistar Rats: Toxicological Study as Mitochondrial Disrupting Agent

BPA is an EDC which is continuously released into the environment because of its extensive usage as plasticizer and other industrial applications. The present study establishes BPA induced alterations in mitochondrial marker enzymes and hence cause mitochondrial dysfunction. Studies were performed to evaluate the histopathological changes in tissue on exposure to different doses of BPA for different time periods.  Light microscopic examination of samples was done to evaluate the possible changes caused by treatment of different doses of BPA. After getting the results in light microscopy the changes and damage caused by BPA ultra-structurally were observed.  Light microscopic study showed that BPA exposure for short duration of 7 days did not resulted in significant change in histology of Rat of treated animals. Light microscopic observations showed that low doses of BPA (5 and 10 mg/kg body weight) exposure for 14 days caused reduction in the number of cells in the layers of seminiferous tubules. Highest dose of BPA treatment for 14 days caused much damage to the seminiferous tubules. There were many ultra-structural changes found in the treated groups as compared to the control group. Hence it can be stated that due to the toxic effect of BPA the mitochondrial marker enzymes have shown marked reduction in their activities. Keywords: BPA, EDCs, Light microscopic, Mitochondria and Toxicity

EFFECT OF ETHANOLIC FRUITS EXTRACT OF EMBELIA RIBES BURM ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN MICE

This study was designed to examine the effect of ethanolic fruits extract of Embelia ribes Burm on dexamethasone-(1mg/kg, intramuscular, 22 days) induced Insulin resistance in Mice. Twenty two  days of oral feeding the extract (100 mg/kg and 200 mg/kg) to induced mice resulted in significant (P < .01) decrease in blood glucose, triglyeride, Insulin, HOMA-IR index and  increase in body weight  levels as compared to dexa control mice. Further, the extract also significantly (P < .01) decreased the MDA levels and significantly (P < .01) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in Hepatic tissue of dexa control  mice and also increased glucose uptake by skeletal muscle. The results of test drug were comparable to pioglitazone (2 mg/kg, i.m , 22 days), a standard antihyperglycemic agent. The study concludes that Embelia ribes enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and Embelia ribes may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance

Effects of aliskiren on hemodynamic parametersin daunorubicin -induced acute cardiomyopathy in rats

Daunorubicin ((DNR)) used in oncological practice against a wide variety of solid organ tumors and hematologic malignancies, including leukemia, lymphoma, breast cancer, lung cancer, multiple myeloma and sarcoma. however clinical use of this agent is limited due to cardiomyopathy and cardiac heart failure. one of the important player in the development of cardic hypertrophy and reperfusion injury is renin-angiotensin system. Aliskiren (ALK) a recent drug of a direct inhibitor of the renin enzyme. It Protect cardiomyopathy by the inhibition of the renin activity. Present study is towards the evaluation of protective effcets of ALK 50 and 100 mg/kg/day in rats. The systolic, diastolic, mean BP and heart rate were significantly (P< 0.01) increased in DNR control group as compared to normal control group. Thus the results provide clear evidence that the ALK pretreatment offered significant protection against DNR-induced Hemodynamic parameters changes.  Keywords: Daunorubicin, Cardiomyopathy, Aliskiren, Telmisartan and Hemodynamic parameter

In-Vivo assessment of glucocorticoid loaded tea tree oil nanoemulsion gel

Optimized formulations were subjected to various in vivo studies like anti-inflammatory activity, Nickel induced dermatitis, irritation study and Acute and repeated dose dermal toxicity studies. Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and antiproliferative activity. The aim of the present work was to test the hypothesis that the addition CP in nanoemulsions would result in enhancement CP delivery and leading to better antipsoriatic activity. Nanoemulsions were prepared by aqueous phase titration method, using Tea Tree oil, Tween 20, Transcutol P, and distilled water as the oil phase, surfactant, co-surfactant and aqueous phase, respectively.We developed a topical O/W nanoemulsion in which drug is incorporated in disperse phase of oil and evaluated its efficacy against different types of in vivostudies. It was also found that the significantly increased their anti-inflammatory activity. It was reported that CP-loaded nanoemulsion significantly increased NTPDase (Nucleoside triphosphate diphosphohydrolases) activity in lymphocytes. This membrane protein is responsible for the hydrolysis of extracellular ATP (Adenosine triphosphate) which is responsible for cell proliferation, differentiation and inflammatory processes. In vivoirritation studies did not show any irritation in spite of having high amount of surfactant. Group treated with CP loaded nanoemulsion gel showed no evident toxicity even on repeated exposure. On the basis of above in vivo study we conclude that developed nanoemulsion is safe for human. Keywords: Clobetasol propionate, In-vivo study, Nanoemulsion, Anti-inflammatory study, Toxicity stud

Hepatoblastoma in an Adult with Biliary Obstruction and Associated Portal Venous Thrombosis

We present a case of adult hepatoblastoma. This young female presented with severe acute cholangitis. Preoperative diagnosis was common bile duct (CBD) obstruction with portal vein thrombosis. On exploration she had a tumor mass in the CBD. The unusual features of this case are discussed in this report

Learning an Executable Neural Semantic Parser

This paper describes a neural semantic parser that maps natural language utterances onto logical forms which can be executed against a task-specific environment, such as a knowledge base or a database, to produce a response. The parser generates tree-structured logical forms with a transition-based approach which combines a generic tree-generation algorithm with domain-general operations defined by the logical language. The generation process is modeled by structured recurrent neural networks, which provide a rich encoding of the sentential context and generation history for making predictions. To tackle mismatches between natural language and logical form tokens, various attention mechanisms are explored. Finally, we consider different training settings for the neural semantic parser, including a fully supervised training where annotated logical forms are given, weakly-supervised training where denotations are provided, and distant supervision where only unlabeled sentences and a knowledge base are available. Experiments across a wide range of datasets demonstrate the effectiveness of our parser.Comment: In Journal of Computational Linguistic

High yield synthesis of boron based nanosheets by chelation assisted exfoliation of layered magnesium diboride towards functional polymer nanocomposites

by Rohit SaraswatM.Tech

High yield synthesis of boron-based nanosheets

We present the chemical exfoliation of magnesium diboride (MgB2) by employing organic chelating agents for synthesising boron-based nanosheets in high yield. MgB2 is a promising parent material towards realising quasi-2D forms of boron, owing to its unique layered constitution: graphenic boron planes interleaved with hexagonal arrays of Mg atoms. Chelating agents can selectively extract the interlayer Mg from MgB2 in water, to form Mg-chelant complexes. The loss of Mg results in delamination of MgB2 into boron-based nanosheets. This approach is further improved by rational choice of chelants with greater affinity for Mg and tuning the optimal pH for metal complexation, thereby leading to a better yield of nanosheets. These boron-based nanosheets have been explored for their candidacy as a new class of inorganic fillers in a polymeric matrix – polyvinyl alcohol (PVA). The mechanical and thermal properties of these boron-based nanosheet-PVA nanocomposite films have been studied.by Rohit Saraswat, Asha Liza James and Kabeer Jasuj